The film stars Dwayne Johnson, Naomie Harris, Malin Åkerman, Jake Lacy, Joe Manganiello, and Jeffrey Dean Morgan. It follows a primatologist who must team up with George, an albino western lowland gorilla who turns into a raging creature of enormous size as a result of a rogue experiment, to stop two other mutated animals from destroying Chicago.

The film is the third collaboration between Peyton and Johnson, following Journey 2: The Mysterious Island (2012) and San Andreas (2015). It also marked the final released Warner Bros. film to be financed by Access Entertainment/RatPac-Dune Entertainment as the studio had ended their partnership with the company due to sexual harassment allegations against RatPac-Dune owner Brett Ratner (which resulted in the company going uncredited); the company subsequently dissolved later that year.

Principal photography began in April 2017 in Chicago. The film was released in the United States on April 13, 2018, by Warner Bros. Pictures, in 2D, RealD 3D and IMAX. The film had grossed over $428 million worldwide and received mixed reviews from critics, with praise for its performances (particularly Johnson and Morgan), action sequences and visual effects, but criticism of its screenplay, pacing and storyline.