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Slither (2006) is a grotesque and thrilling blend of horror and dark comedy, directed by James Gunn. The film introduces a small town that becomes the epicenter of a terrifying alien infestation, bringing body horror, grotesque mutations, and plenty of twisted humor.

The story begins in Wheelsy, a quiet rural town where a meteor crashes, releasing a parasitic alien organism. Grant Grant (Michael Rooker), a local businessman, is the first to be infected after encountering a strange, slithering creature in the woods. His body slowly transforms in horrifying ways as the parasite takes control, and he begins spreading the infection to others, turning them into grotesque, mind-controlled monstrosities.

As the alien plague spreads, Sheriff Bill Pardy (Nathan Fillion) and Starla Grant (Elizabeth Banks), Grant’s wife, desperately fight to contain the growing nightmare. The town is soon overrun by mutant creatures, grotesque slug-like parasites, and zombified townspeople all controlled by a hive mind. The infestation escalates into full-blown chaos, with people being absorbed into a grotesque, fleshy mass controlled by the parasitic entity.

With its mix of body horror, gory practical effects, and sharp comedic timing, Slither pays homage to classic ’80s horror films while maintaining its own unique charm. James Gunn masterfully balances horror and humor, delivering a film that is both terrifying and darkly entertaining. With Nathan Fillion’s charismatic hero, Elizabeth Banks’ strong-willed survivor, and Michael Rooker’s unforgettable transformation, Slither is a cult classic that remains a must-watch for horror-comedy fans.